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Inventi Impact: Pharmaceutical Process Development

Articles

  • Inventi:ppd/32073/20
    Quality by Design Optimization of Cold Sonochemical\nSynthesis of Zidovudine-Lamivudine\nNanosuspensions
    Research 2020 : July - September
    Bwalya A Witika, Vincent J Smith, Roderick B Walker

    Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used to manage HIV/AIDS\ninfection. The compounds require frequent dosing, exhibit unpredictable bioavailability and a side\neffect profile that includes hepato- and haema-toxicity. A novel pseudo one-solvent bottom-up\napproach and Design of Experiments using sodium dodecyl sulphate (SDS) and Alpha-tocopheryl\npolyethylene glycol succinate 1000 (TPGS 1000) to electrosterically stablize the nano co-crystals was\nused to develop, produce and optimize 3TC and AZT nano co-crystals. Equimolar solutions of 3TC\nin surfactant dissolved in de-ionised water and AZT in methanol were rapidly injected into a vessel...............

    How to Cite this Article
    Attribution/ CC Compliant Citation:Witika, Bwalya A., Vincent J. Smith, and Roderick B. Walker. \"Quality by Design\nOptimization of Cold Sonochemical Synthesis of Zidovudine-Lamivudine Nanosuspensions.\" Pharmaceutics 12.4 (2020): 367.\nhttps://doi.org/10.3390/pharmaceutics12040367\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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